Application of continuing nursing care based on Wechat platform in patients with psoriasis by injecting tumor necrosis factor-α antagonist at home / 中国实用护理杂志

Objective:To observe the effect of continuous nursing care based on Wechat platform on the drug safety and compliance in patients with psoriasis at home injection of tumor necrosis factor α (TNF-α) antagonists, so as to provide guidance for patients to use biological agents safely and effectively at home.Methods:A total of 86 patients with moderate to severe psoriasis who were discharged from Dalian Dermatology Hospital from January to December 2020, injected with TNF-α antagonist at home were selected as the study subjects. They were divided into control group and observation group by random digits table method with 43 cases in each group. The control group received routine injection guidance and telephone follow-up; the observation group used continuous nursing care based on Wechat platform on the basis of the control group. Three months after discharge, the medication compliance of the two groups was evaluated by Morisky Medication Adherence Scale-8 (MMAS-8). Before discharge and three months after discharge, the efficacy of the two groups was evaluated by psoriasis area and severity index (PASI). One month after discharge, the adverse reactions of the two groups were counted.Results:The MMAS-8 score was 7.26 ± 1.28 in the observation group and 5.13 ± 1.42 in the control group three months after discharge, the difference was statistically significant ( t = 7.31, P<0.01). There was no significant difference in PASI score between the two groups before discharge ( P>0.05). Three months after discharge, the PASI score was 2.69 ± 1.45 in the observation group and 5.74 ± 1.32 in the control group, the difference was statistically significant ( t = 10.12, P<0.01). The total effective rate was 97.67% (42/43) in the observation group and 93.02% (40/43) in the control group, the difference was statistically significant ( χ2 = 2.35, P<0.05). The incidence of adverse reactions was 6.98% (3/43) in the observation group and 18.60% (8/43) in the control group, the difference was statistically significant ( χ2 = 6.05, P<0.05). Conclusions:In the treatment of patients with psoriasis who inject TNF-α antagonists at home, supplemented with continuous nursing based on Wechat platform can effectively reduce adverse reactions, improve their medication compliance, and improve the safety of home injections Sexuality and effectiveness.

Incidence of central nervous system metastases in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer treated with trastuzumab: A meta-analysis

This study aimed to estimate the incidence of central nervous system (CNS) metastases in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) treated with trastuzumab. Studies were identified through a literature search of electronic databases. Random-effects meta-analyses were performed to estimate the incidence rate of CNS metastases, trastuzumab therapy duration, and time from trastuzumab therapy to CNS metastasis diagnosis. A meta-analysis of odds ratios was performed to evaluate the significance of a difference in CNS metastasis incidence between patients with and without trastuzumab treatment. Thirty studies (8121 trastuzumab-treated and 3972 control patients) were included. The follow-up duration was 18.9 months (95% confidence interval [CI]: 13.8, 24.1). The trastuzumab treatment duration was 9.0 months (95% CI: 7.0, 11.0). The median interval between the start of trastuzumab therapy and CNS metastasis diagnosis was 12.2 months (95% CI: 9.5, 14.7). The incidence of CNS metastasis after the start of trastuzumab therapy was 22% (95% CI: 16, 27). The incidence of CNS metastases was significantly higher in trastuzumab-treated than in non-trastuzumab-treated patients (odds ratio: 1.39 [95% CI: 1.06, 1.82], p=0.02). The survival time from the start of the study was 23.4 months (95% CI: 19.7, 27.1) in trastuzumab-treated patients and 18.4 months (95% CI: 12.7, 24.1) in patients treated with control regimens. The survival time after the development of CNS metastases in trastuzumab-treated patients was 19.2 months (95% CI: 15.6, 25.9). Approximately 22% of patients with HER2-positive MBC who were treated with trastuzumab developed CNS metastases. However, trastuzumab-treated patients had a longer survival than patients who were not treated with trastuzumab.

A cross-sectional survey of current supportive care needs in patients with psoriasis / 中国实用护理杂志

Objective:To investigate the levels of supportive care needs of patients with psoriasis, and to master the unmet care needs of psoriasis patients, so as to provide reference for the development of personalized care plan for patients with psoriasis.Methods:The convenience sampling method was used to investigate the inpatients with psoriasis from April to May in 2020 by using the Support Care Needs Scale-Short Form 34 (SCNS-SF34). The patients came from 15 dermatology hospitals and tertiary general hospitals with dermatology inpatients of 14 provinces and municipalities.Results:The total scores of each item of SCNS-SF34 were as followed: health information needs was 35.72 ± 14.14, the psychological needs was 28.07 ± 11.37, the physical and daily life needs of was 13.03 ± 5.85, the care and support needs was 14.34 ± 6.07, the sexual needs was 6.75 ± 3.47.Conclusions:Psoriasis patients in many ways are not satisfied with the need for care. Patients should receive personalized professional psychological guidance. In order to meet the patients' nursing and support needs, including sexual needs, physiological needs and daily needs, attention should be paid to and innovative access to health information and disease guidance knowledge.

Effect of 321 health education guided by transtheoretical model on symptom groups of hemodialysis patients / 中国实用护理杂志

Objective:To explore the intervention effect of 321 health education guided by transtheoretical model on hemodialysis patients.Methods:A total of 107 cases of hemodialysis patients from January to December in 2019 in the Central Hospital of Panzhihua, Sichuan Province, were divided into a control group of 53 cases and a study group of 54 cases by table of random number. Patients in the control group received routine health education, and patients in the study group were intervened by 321 health education guided by transtheoretical model. The level of health literacy, symptoms, quality of life of patients in the two groups were evaluated by chronic disease patients health literacy scale, the Chinese version of Dialysis Frequency Severity and Symptom Burden Index (DFSSBI), and the Chinese version of Kidney Disease Questionnaire (KDQ) before and after the intervention.Results:After the intervention, the total score of the health literacy scale of patients with chronic diseases in the control group and the score of the three dimensions of information acquisition ability, communication and interaction ability, and willingness to be healthy were (89.16±11.04), (32.62±3.51), (31.48±3.61), (16.85±2.57), lower than those of the study group (99.86±11.46),(35.92±3.42),(35.73±3.92),(19.96±2.77), respectively, and the differences were statistically significant ( t values were -21.898--4.925, P<0.01). After the intervention, the total score, physical symptom score and psychological symptom score of the two dimensions of DFSSBI in the control group were (56.39 ± 8.21), (47.27 ± 6.85), (9.12 ± 1.31),higher than those of the control group (49.00 ± 6.31), (41.81 ± 5.35), (7.17 ± 0.95),respectively, and the differences were statistically significant ( t values were 5.226, 4.599, 8.827, P<0.01). After the intervention, the incidence of difficulty in falling asleep, fatigue, dry skin, itching, dry mouth in the study group were 38.89%(21/54), 38.89%(21/54), 27.78%(15/54), 27.78%(15/54), 25.93%(14/54), lower than those in the control group 66.04%(35/53), 62.26%(33/53), 49.06%(26/53), 49.06%(26/53), 45.28%(29/53), respectively, and the differences were statistically significant(χ 2 values were 5.124-9.224, P<0.05 or <0.01). The symptom scores of difficulty in falling asleep, fatigue, dry skin, itching, dry mouth in the control group were (7.44 ± 0.81), (7.34 ± 0.72), (7.42 ± 0.73), (8.62 ± 0.72), (7.82 ± 0.77), higher than those in the study group(6.11 ± 0.65), (6.02 ± 0.59), (6.15 ± 0.61), (7.12 ± 0.65), (5.84 ± 0.51) respectively, and the differences were statistically significant ( t values were 9.376-15.710, P<0.01). After the intervention, the total score of KDQ and the scores of physical symptoms, fatigue and depression in the control group were (106.46 ± 13.39), (23.87 ± 2.40), (22.71 ± 2.67), (22.52 ± 2.93), lower than those in the study group (116.89 ± 14.59), (27.12 ± 2.53), (25.16 ± 2.82), (27.12 ± 3.75), respectively, and the differences were statistically significant ( t values were -7.062--3.851, P<0.01). Conclusions:Intervention of 321 health education guided by transtheoretical model on hemodialysis patients can improve their health literacy and symptoms, reduce their symptom burden score and improve their quality of life.

Influences of 321 health education model on pruritus status of maintenance hemodialysis patients / 中国实用护理杂志

Objective:To explore the nursing efficacy of 321 health education model on maintenance hemodialysis patients with itchy skin.Methods:A total of 97 cases of maintenance hemodialysis patients with itchy skin from January 2019 to December 2019 in the Central Hospital of Panzhihua were divided into control group of 49 cases and study group of 48 cases by table of random number. The patients in control group were taken with conventional nursing and health propaganda measures while the patients in study group accepted a different nursing mode of combining 321 health education model. The Chinese version of the Four-Item Itch Questionnaire (FIIQ), the Chinese version of the Dermatology Life Quality Index (DLQI), and the Chinese version of the Kidney Disease Questionnaire (KDQ) were used to evaluate the skin itchy status and its influences to patients′ life and life quality of the 2 groups before and after intervention.Results:There was no significant difference in the skin itchy status and its influences to patients′ life and life quality before intervention between the two groups( P>0.05). After intervention, the total score of FIIQ, and the scores of the three dimensions of itchy degree, itchy frequency, and influences on sleep were respectively (7.46 ± 0.94), (1.83 ± 0.26), (1.92 ± 0.29), (1.86 ± 0.23), which were all lower than the same data of the control group patients: (12.36 ± 1.24), (2.69 ± 0.31), (3.02 ± 0.42), (2.91 ± 0.37), showing differences with statistical significance ( t values were 14.79-21.90, P<0.05). After intervention, the total score of the DLQI, and the scores of five dimensions of symptom perception, daily life, entertainment and leisure, work and study, and treatment of the patients in study group were respectively (10.55 ± 1.27), (2.85 ± 0.29), (2.11 ± 0.32), (2.47 ± 0.29), (1.72 ± 0.25), and (2.21 ± 0.27), which were all lower than the same data of patients in control group: (14.47 ± 1.78), (3.92 ± 0.37), (1.57 ± 0.22), (1.64 ± 0.25), (1.26 ± 0.18), (1.21 ± 0.11), indicating statistically significant difference ( t values were 9.67-23.80, P<0.05). After intervention, the total score of KDQ and the scores of the four dimensions of physical symptoms, fatigue, depression, and frustration of the patients in study group were respectively (121.66 ± 15.91), (27.36 ± 3.02), (24.44 ± 3.44), (26.71 ± 3.58), and (19.28 ± 2.66), which were all higher than the same data of patients in control group: (108.38 ± 14.69), (24.51 ± 2.64), (22.60 ± 3.41), (22.45 ± 3.47), (14.92 ± 2.04), presenting differences with statistical significance ( t values were -9.07 - -2.65, P<0.05). Conclusions:For maintenance hemodialysis patients with itchy skin, the nursing intervention by 321 health education model can effectively ease the itchy skin problem, relieve the impact of itchy skin on patients' lives, and improve the life quality of patients.

Application effect of continuation nursing model based on Omaha system theory in psoriasis / 中国实用护理杂志

Objective:To explore the effect of extended nursing based on Omaha system in patients with psoriasis.Methods:A total of 133 hospitalized patients with psoriasis from September to December 2018 were selected and divided into 66 patients in the intervention group and 67 patients in the control group according to random number table method.The control group was given routine nursing guidance and health education, and the intervention group adopted the Omaha system of continuing care program on this basis.The changes of skin disease quality of life, health cognitive behavior, Psoriasis Area and Severity Index (PASI) scores were compared between the two groups before and after nursing.Results:There was no significant difference in skin disease quality of life, health cognitive behavior, PASI before nursing between the two groups( P >0.05). The score of skin disease quality of life in the observation group was 6.29±2.09, significantly lower than that in the control group (9.41±3.17), and the difference was statistically significant ( t value was -9.661, P<0.05). The scores of knowledge, behavior and status of the observation group were 58.33±20.52, 41.39±14.26, 52.68±18.74,significantly higher than those of the control group(45.72±18.17, 38.64±15.37, 43.37±16.43), and the difference were statistically significant( t values were 9.744,6.138,5.751,all P <0.05). The PASI score of the intervention group was 2.05±0.94, lower than that of the control group (2.84±1.12), and the difference was statistically significant ( t value was 1.557, P <0.05). Conclusions:The application of Omaha system psoriasis continuous care program, significantly improves the health awareness of patients with psoriasis, changes bad health behavior, improves health status, promotes the disappearance of skin lesions, and improves their quality of life.

Evaluation of the reproducibility of non-verbal facial expressions in normal persons using dynamic stereophotogrammetric system / 北京大学学报(医学版)

OBJECTIVE@#To assess the reproducibility of non-verbal facial expressions (smile lips closed, smile lips open, lip purse, cheek puff) in normal persons using dynamic three-dimensional (3D) imaging and provide reference data for future research.@*METHODS@#In this study, 15 adults (7 males and 8 females) without facial asymmetry and facial nerve dysfunction were recruited. Each participant was seated upright in front of the 3D imaging system in natural head position. The whole face could be captured in all six cameras. The dynamic 3D system captured 60 3D images per second. Four facial expressions were included: smile lips closed, smile lips open, lip purse, and cheek puff. Before starting, we instructed the subjects to make facial expressions to develop muscle memory. During recording, each facial expression took about 3 to 4 seconds. At least 1 week later, the procedure was repeated. The rest position (T0) was considered as the base frame. The first quartile of expressions (T1), just after reaching the maximum state of expressions (T2), just before the end of maximum state of expressions (T3), the third quartile of expressions (T4), and the end of motion (T5) were selected as key frames. Using the stable part of face such as forehead, each key frame (T1-T5) of the different expressions was aligned on the corresponding frame at rest (T0). The root mean square (RMS) between each key frame and its corresponding frame at rest were calculated. The Wilcoxon signed ranks test was applied to assess statistical differences between the corresponding frames of the different facial expressions.@*RESULTS@#Facial expressions like smile lips closed, smile lips open, and cheek puff were reproducible. Lip purse was not reproducible. The statistically significant differences were found on the T2 frame of the repeated lip purse movement.@*CONCLUSION@#The dynamic 3D imaging can be used to evaluate the reproducibility of facial expressions. Compared with the qualitative analysis and two-dimensions analysis, dynamic 3D images can be able to more truly represent the facial expressions which make the research more reliable.

Comparative study on hearing status of preeclampsia infants with different degrees of hypertensive disorder complicating pregnancy and preeclampsia infants without hypertensive disorder complicating pregnancy / 中国实用妇科与产科杂志

OBJECTIVE: To explore the influence and significance of preeclampsia with different degrees of gestational hypertension on infant hearing.METHODS: Totally 1046 newborns whose mothers had a history of pre-eclampsia with hypertensive disorder complicating pregnancy were divided into groups according to the severity of pre-eclampsia and whether they were premature or not from Jan. 2015 to Dec. 2017 in the Forth Hospital of Shijiazhuang.Hearing tests were conducted and compared with newborns whose mothers had no history of pre-eclampsia with hypertensive disorder complicating pregnancy.RESULTS: Of the 14 741 infants studied,57 were finally diagnosed with sensorineural hearing loss,with a total abnormality rate of 0.39%(57/14 741).Among them,34 infants with pre-eclampsia without hypertensive disorder complicating pregnancy had an abnormality rate of 0.25%.There were 12 infants with mild preeclampsia in their mothers,with an abnormality rate of 1.47%.There were 11 infants whose mothers had severe preeclampsia,with an abnormality rate of 4.76%.There were significant differences between mild group and control group,severe group and control group,and severe group and mild group(P0.05),but there was significant difference between the severe group and the control group,and between the severe group and the mild group(P<0.01 and P<0.05,respectively).CONCLUSION: Premature infants with severe hypertensive disorder complicating pregnancy and preeclampsia are at high risk of hearing impairment.The higher the degree of hypertension,the higher the rate of hearing impairment.The emphasis should be put on strengthening the hearing monitoring and follow-up of such children.

Numerical analysis of the influence of otitis media on the hearing compensation performance of round-window stimulation / 生物医学工程学杂志

In order to study the influence of tympanic membrane lesion and ossicular erosion caused by otitis media on the hearing compensation performance of round-window stimulation, a human ear finite element model including cochlear asymmetric structure was established by computed tomography (CT) technique and reverse engineering technique. The reliability of the model was verified by comparing with the published experimental data. Based on this model, the tympanic membrane lesion and ossicular erosion caused by otitis media were simulated by changing the corresponding tissue structure. Besides, these simulated diseases' effects on the round-window stimulation were studied by comparing the corresponding basilar-membrane's displacement at the frequency-dependent characteristic position. The results show that the thickening and the hardening of the tympanic membrane mainly deteriorated the hearing compensation performance of round-window stimulation in the low frequency; tympanic membrane perforation and the minor erosion of ossicle with ossicular chain connected slightly effected the hearing compensation performance of round-window stimulation. Whereas, different from the influence of the aforementioned lesions, the ossicular erosion involving the ossicular chain detachment increased its influence on performance of round-window stimulation at the low frequency. Therefore, the effect of otitis media on the hearing compensation performance of round-window stimulation should be considered comprehensively when designing its actuator, especially the low-frequency deterioration caused by the thickening and the hardening of the tympanic membrane; the actuator's low-frequency output should be enhanced accordingly to ensure its postoperative hearing compensation performance.

Investigation of aflatoxins,mycobiota,and toxigenic fungi during post-harvest handling of Ziziphi Spinosae Semen / 中国中药杂志

Ziziphi Spinosae Semen is one of the Chinese herbal medicine being susceptible to aflatoxins contamination. To investigate the sources of aflatoxins contamination and toxigenic fungi species on Ziziphi Spinosae Semen,32 samples were collected from multiple steps during the post-harvest processing in this study. Aflatoxins in these samples were determined by immunoaffinity column and HPLC coupled with post-column photochemical derivatization. The dilution-plate method was applied to the fungi isolation. The isolated fungi strains were identified by morphological characterization and molecular approaches. The results showed that aflatoxins were detected in 28 samples from every step during the processing of Ziziphi Spinosae Semen. Three samples were detected with aflatoxin B_1 and 2 samples with both aflatoxin B_1 and total aflatoxin exceeding the limit of Chinese Pharmacopoeia. Especially the samples from the washing step,with the highest detected amounts of AFB_1 and AFs were reached 94. 79,121. 43 μg·kg~(-1),respectively. All 32 samples were contaminated by fungi. The fungal counts on the newly harvested samples were 2. 20 × 10~2 CFU·g~(-1). Moreover,it increased as tphreocessing progresses,and achieved 1. 16×10~6 CFU·g~(-1) after washing. A total of 321 isolates were identified to 17 genera. Aspergillus flavus was the main source of aflatoxins during the processing and storage of Ziziphi Spinosae Semen. One isolate of A. flavus was confirmed producing AFB_1 and AFB_2. The fungal count was significantly increased by composting,and Aspergillus was the predominant genus after shell breaking. The contamination level of aflatoxins was increased by composting and washing.

Effects of gastrodin against SH-SY5Y cell autophagy induced by methamphetamine and underlying mechanisms / 中国药理学通报

Aim To investigate the effects of gastrodin on SH-SY5Y cell autophagy induced by methamphet-amine (METH) and the underlying mechanisms. Methods SY5Y cells were treated by METH with the concentration of 0.5,1.0,1.5,2.0,2.5,3.0 mmol·L-1for 24 h. The morphological changes were ob-served by microscopy,the expression of LC3-Ⅱ,Bec-lin-1,Akt,p-Akt,mTOR and p-mTOR were detected by Western blot. Gastrodin was added to the medium 1 h before METH treatment. Results The SY 5 Y cells were morphologically featured by shrinkage and den-drite disruption after exposed to METH(0~3 mmol· L-1),and autophagic vacuoles occurred in cytoplasm. The expression of LC3-Ⅱ increased over METH dose. Confocal results showed that LC3-Ⅱsignificantly in-creased in METH group as compared with control, while decreased in METH+ Gastrodin group. The ex-pression levels of LC3-Ⅱand Beclin-1 significantly in-creased (P<0.01) in METH group, p-mTOR and p-Akt decreased, and mTOR and Akt showed no signifi-cant difference as compared with control. However, the gastrodin could decrease the expression of LC3-Ⅱand Beclin-1 and increase the expression of mTOR,p-mTOR,Akt and p-Akt as compared with METH-trea-ted groups. Conclusions METH can induce SY5Y cells autophagy. The protective effect of gastrodin a-gainst METH-induced autophag may be related to gast-rodin regulation mTOR and Akt signaling pathway.

Determination of 13 Kinds of Sulfonylurea Herbicides Residues in Aquatic Products by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry / 分析化学

A sensitive method was proposed for determination of 13 kinds of sulfonylurea herbicides residues in aquatic products by solid phase extraction-ultra performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (SPE-UPLC-MS/MS). The edible part of carp, penaeus vannamei,crab,clam and sea cucumber were collected and homogenized. Analytes was extracted with ethyl acetate,and then cleaned up by MAX solid phase extraction column. Qualitation of the analytes was achieved with multiple reaction monitoring (MRM) and the external standard method was used for quantification. The 13 kinds of sulfonylurea herbicides showed good linearity in the concentration range of 5.0-100.0 μg/L respectively. The detection limits of the 13 analytes were 1.0 μg/kg, and the limit of quantification was 2.0 μg/kg. The average recoveries ranged from 75.4% to 118.3% with relative standard deviations from 2.1% to 14.5%. The 13 target analytes were not detected in grass carp,carp,sea cucumber,prawn,turbot of breeding and crabs from the market. The halosulfuron-methyl was detected in the edible tissues of crabs exposed to a 1.0 mg/L halosulfuron-methyl solution for 24,48 and 72 h,and the concentrations were 6.20, 12.1 and 16. 6 μg/kg respectively. The method can be stable and sensitive, and is applied to the determination of 13 kinds of sulfonylurea herbicides residues in aquatic products.

Effect of PCI revascularization degree on exercise tolerance in patients with multivessel coronary artery disease / 重庆医学

Objective To explore the effect of percutaneous coronary intervention(PCI) revascularization degree on exercise tolerance in the patients with multivessel coronary heart disease(CHD).Methods Ninety-three cases of coronary multivessel disease undergoing PCI revascularization and completing the cardiopulmonary exercise testing(CPET) were selected and divided into the complete revascularization group(CR group) and incomplete revascularization group(ICR group).The patients' general condition,co-existence diseases,medication,CHD and vessel lesion situation,echocardiography and CPET results at revascularization and within 1 week of CPET in the two groups were collected.Then the exercise tolerance was evaluated and compared between the two groups.Results The peak metabolic equivalent in the CR group and ICR group were 6.1(3.0-11.0) Mets and 6.3 (3.0-9.0) Mets;the VO2 at anaerobic threshold were 16.3(4.0-23.0) mL · kg-1 · min-1 and 15.9(4.0-26.0) mL · kg-1 · min-1,respectively;the peak VO2 were 21.1(13.0-35.0) mL · kg-1 · min-1 and 21.9(13.0-31.0) mL · kg-1 · min-1,respectively(P=0.919,0.350,0.991).Conclusion For the patients with multivessel CHD receiving ICR,their exercise tolerance is not inferior to those receiving CR.

Risk factors for perioperative myocardial infarction in aged patients undergoing nonneurologic and noncardiac surgery / 中华老年医学杂志

Objective To explore the risk factors for perioperative myocardial infarction(PMI) in aged patients undergoing nonneurologic and noncardiac surgery.Methods A total of 9285 inpatients aged 65 or above receiving nonneurologic and noncardiac surgery at Peking University People's Hospital from November 2012 to May 2016 were retrospectively recruited to our study.Patients who had suffered PMI were assigned to a myocardial infarction group(MI group)and others were allocated to a nonmyocardial infarction group(non-MI group).Clinical manifestations,comorbidities,preoperative laboratory test results,polypharmacy,characteristics of operation and anesthesia,and prognosis were analyzed and compared between the two groups.A multivariate logistic regression model was built to evaluate risk factors for PMI in aged patients undergoing nonneurologic and noncardiac surgery.Results PMI occurred in 12 patients(0.13％).Previous stroke or transient ischemic attack(TIA) history (OR =159.254,P ＜ 0.001),cardiovascular heart disease (CHD) history (OR=33.645,P ＜0.001),and chronic kidney disease(CKD) (OR =19.393,P =0.003) were independent risk factors for PMI in aged patients undergoing nonneurologic and noncardiac surgery.PMI was associated with longer hospitalization[29 (15 59) days vs.9 (6-15) days,P ＜ 0.001] and higher mortality(58.3 ％).Conclusions Previous stroke or TIA history,CHD history,and CKD are independent risk factors for PMI in aged patients undergoing nonneurologic and noncardiac surgery.The incidence of PMI in patients with these risk factors is not high,but the mortality will be high and hospitalization will be prolonged once PMI occurs.Patients with these characteristics need more careful perioperative care.

Progress of Functional Imaging in Brain Structure and Functional Changes in People with Amphetamine Addiction / 昆明医科大学学报

Amphetamines abuse is defined as a chronic recurrent encephalopathy, and it is a global public health problem which seriously threatens the health of human and the social stability. Long-term abuse and addiction of amphetamines leads to structural and functional changes of specific encephalic regions. Further researches on these encephalic regions, the network of brain and biological information may be helpful to understanding drug abuse mechanism and possible therapeutic measures. Recently, a series of functional imaging techniques, including magnetic resonance imaging (MRI), functional magnetic resonance imaging (f MRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and positron emission tomography (PET), were used to detect different brain structural changes of the volume and density of encephalic regions, functional changes of cerebral blood flow and brain cognition. The results showed functional imaging techniques play significant roles to detect different structural and functional changes of the brain. Based on these results, the researchers aim to clarify the mechanisms of drug abuse. That is the main focus of this review.

Determination of Polysaccharide Content in Dried Peel of Seeding Watermelon and Its Mechanism of Lowering Blood Glucose / 医药导报

Objective Determination of polysaccharide content in dried peel seeding watermelon, and its mechanism of lowering blood glucose.Methods The content of polysaccharides in dried peel of seeding watermelon was determined by the method of phenol-sulfuric acid.Mice were given starch and sucrose load,and the mouse blood glucose was examined.The inhibitory activities of seeding watermelon against α-glucosidase were tested by the colorimetry of pNPG.Results The calibration of polysaccharide was A=0.066 4 C+0.022 6, R2=0.999 5, the content of polysaccharide in dried peel of seeding watermelon was 4.45% (n=10,RSD=1.80%);50,100 and 150 mg·kg-1 of polysaccharide could significantly reduce the starch load in mice blood glucose(P<0.01);100 and 150 mg·kg-1 of polysaccharide significantly reduced sucrose load blood glucose(P<0.01);polysaccharide concentration in 18 mg·mL-1 could significantly inhibit the activity of α-glucosidase as the inhibitory rate was (73.19±3.45)% (n=10).Conclusion Seeding watermelon polysaccharide has effect on lowering blood glucose in starch and sucrose load mice, and inhibits α-glucosidase significantly.

Evaluation of Verbal Communication Ability in Old People:An Algorithm Based on Fuzzy Principal Component Analysis / 中国康复理论与实践

Objective To quantify the results of the assessment of verbal communication ability in old people,to establish a graded nurs-ing service for the senior.Methods From March,2016 to May,2017,50 old volunteers in the nursing home and hospital were assessed the verbal communication ability with language barrier diagnosis and treatment apparatus ZM2.1.The indexes were analyzed with a fuzzy com-prehensive and principal component quantitative analysis model,to grade the verbal communicative ability.The results were compared with that of the clinic.Results Two principal components were extracted,with the variance contribution rates of 77.53% and 14.12%,and was cu-mulative to 91.65%.The consistency was not less than 80% from the results of the clinical assessment.Conclusion It is feasible to quantify the verbal communication ability in the old people with fuzzy principal component analysis.

Mechanisms of probiotics to improve type 2 diabetes mellitus / 上海交通大学学报（医学版）

There are tens of thousands of microbiota in the intestine, and the balance of these microbiota is essential to maintain intestinal stability and body metabolism. Once the intestinal flora structure is disordered, a variety of metabolic diseases will follow. In recent years, the international scientific researches focus on the relationship between intestinal flora and metabolic diseases, especially type 2 diabetes mellitus (T2DM). And the probiotics, as a kind of active microorganism that regulate the micro-ecological balance of the host's gut, can change the intestinal flora and their metabolites, and thus improve the host energy metabolism and reduce low level chronic inflammation and oxidative stress. Therefore, its intake has gradually become an usual method of preventing and controlling T2DM. This review provides an overview of the effects of probiotics on host intestinal flora and the mechanisms of improving T2DM, as well as a theoretical reference for the clinical application of probiotics.

Mechanisms of probiotics to improve type 2 diabetes mellitus / 上海交通大学学报（医学版）

There are tens of thousands of microbiota in the intestine, and the balance of these microbiota is essential to maintain intestinal stability and body metabolism. Once the intestinal flora structure is disordered, a variety of metabolic diseases will follow. In recent years, the international scientific researches focus on the relationship between intestinal flora and metabolic diseases, especially type 2 diabetes mellitus (T2DM). And the probiotics, as a kind of active microorganism that regulate the micro-ecological balance of the host's gut, can change the intestinal flora and their metabolites, and thus improve the host energy metabolism and reduce low level chronic inflammation and oxidative stress. Therefore, its intake has gradually become an usual method of preventing and controlling T2DM. This review provides an overview of the effects of probiotics on host intestinal flora and the mechanisms of improving T2DM, as well as a theoretical reference for the clinical application of probiotics.

Three-dimensional finite element analysis on the novel locking plate and AO-PHILOS plate for fixing four-part proximal humeral fractures / 医用生物力学

Objective To compare biomechanical performance of four-part proximal humeral fractures fixed by novel locking plate or by AO-PHILOS plate. Methods The finite element fixation models of both the novel locking plate and AO-PHILOS plate for four-part proximal humeral fractures were established, respectively. The maximum Von Mises stress and displacement under 4 different functional positions of shoulder abduction in the two fixation models were compared by finite element analysis. Results The maximum displacement in shoulder abduction of 0°,30°,60°,90° were 6.644, 7.079, 5.850, 3.005 mm, respectively, in novel locking plate fixation model, and 6.293, 6.826, 5.774, 3.023 mm, respectively, in AO-PHILOS plate fixation model. Since the maximum displacements in both fracture fixation models were similar, it indicated that there was no significant difference in the stability for fixing proximal humeral fracture. The maximum Von Mises stress in shoulder abduction of 0°,30°,60°,90°were 1 033.0, 904.1, 888.1, 1 062.0 MPa in novel locking plate fixation model, while in AO-PHILOS plate fixation model, it showed 743.1, 692.4,486.4,393.5 MPa, respectively. During the process of shoulder abduction, the total stress in both fracture fixation models gradually decreased, but the new locking plate decreased in a larger range, showing an obvious stress dispersion. Conclusions Both the novel locking plate and AO-PHILOS plate can be used as internal fixation treatment for complex four-part proximal humeral fractures with no significant difference in stress distribution, and both showing a stable fixation effect. For fixing proximal humeral fractures with osteoporosis combined with the great and less tuberosity, the novel locking plate has an advantage over AO-PHILOS plate due to its unique anatomical wings and better fixing effect.